Hormonal Balance in PCOS Support

By 5th Jul 2020 Jul 30th, 2020 Lifestyle

Hormonal Balance for PCOS

Lifesource Pcos

This formula HELPS REGULATE the major PCOS hormone imbalances:

ANDROGEN (including testosterone) EXCESS

OESTROGEN EXCESS

PROGESTERONE DEFICIENCY

These 3 are the UNHOLY HORMONE TRIAD of PCOS and are responsible for many of the symptoms of PCOS

HIGH ANDROGENS what do they do?:

  • Cause HAIR GROWTH where you do not want it (face, chest, legs, abdomen)
  • LOSS of HEAD HAIR, ACNE, OILY SKIN, DARK SKIN PATCHES around neck, armpits, groin.
  • High androgens convert to OESTROGENS by the enzyme AROMATASE

HIGH OESTROGENS: what do they do?

High oestrogens worsen PCOS by promoting

  • weight gain
  • food cravings
  • fluid retention
  • anxiety
  • breast tenderness
  • heavy periods (if they occur)
  • PMT
  • suppression of pituitary hormone FSH, stopping normal maturation of follicle resulting in no ovulation.

High oestrogens cause auto-immunity. This means the immune system makes antibodies to attack body tissues including

  1. the thyroid (more weight gain),
  2. the pancreas
  3. insulin receptors (insulin resistance causing high insulin levels)

All of which adversely affect ovaries. Preventing follicle maturation, stopping ovulation and making excessive androgens and oestrogens from the ovaries and weight gain from multiple causes.

LOW PROGESTERONE

Progesterone is low in PCOS for mainly these 3 many reasons.

  • Poor follicle maturation
  • no ovulation
  • no corpus luteum (the left over sac after ovulation that makes progesterone)

Low progesterone results in

  • agitation
  • poor sleep
  • anxiety
  • fluid retention
  • breast tenderness
  • PMT
  • disturbed cycle
  • long and possibly heavy period

PCOS SUPPORT Hormone Balance ingredients:

CHASTE TREE

The berries of the tree Vitus Agnus Castus which helps progesterone production to:

  • improve the chance of ovulation and fertility
  • downgrade oestrogens
  • offset testosterone from making an even stronger androgen Dihydrotestosterone
  • improve mood
  • calmness and sleep
  • reduce anxiety
  • downgrade androgens at many levels, act as a diuretic to lose excess fluid
Deeper explanation:

Women with PCOS often have intermittent or no ovulation, irregular cycles and poor fertility. Anovulatory PCOS women are unlikely to produce adequate progesterone. Progesterone deficiency is often ‘overlooked’ in PCOS patients. Progesterone deficiency, with oestrogen, androgen, insulin and glucose excess can induce a sustained hypothalamic signal (Gonadotrophin Releasing Hormone [GnRH]) level to the pituitary causing disturbed pituitary signaling to ovaries resulting in a disturbed cycle, with poor ovulation, irregular length of cycle and a risk of infertility. 

Supporting progesterone production may assist in increasing fertility. Interestingly, progesterone deficiency is rarely directly discussed in PCOS but implied.

Understanding this further

A hormonal marker of PCOS is the:

  • FSH/LH ratio.

Chronic Low FSH/LH implies disturbed hypothalamic signaling to the pituitary with raised Gonadotrophin Releasing Hormone [GnRH]) from the hypothalamus to the pituitary. There is raised LH levels, LH/FSH ratio, and LH pulse frequency and amplitude in women with PCOS.

A high LH surge in healthy women releases the egg from the mature follicle with subsequent increase in progesterone. However, this does not occur in PCOS, as the follicle do not mature due to suppressed FSH and the sustained high LH causes the production of androgens (male hormones) by the theca cells of the ovaries. High androgens drive further GnRH.

To assist with ovarian regulation, the complimentary PCOS Metabolic contains Myo-inositol (MI) and D-Chiro Inositol (DCI) complex. MI and DCI have been shown to support ovarian function. 

This imbalance of high oestrogen, low progesterone and high androgens are the effect and also cause ongoing endocrine dysfunction in PCOS.

A chronic low FSH/LH ratio suggests a more disorganized hormonal balance with low progesterone and high oestrogen, a toxic combination for the ovaries, uterus, weight management with resultant weight gain, worsening insulin resistance, thyroid dysfunction and auto-immune dysfunction.

In summary:

Addressing progesterone therefore becomes an interesting and supportive factor in attempting to organize hormone function to improve symptoms in PCOS sufferers. Positive effects for Chaste Tree (Vitex agnus-castus) in women with prolonged cycles (oligomenorrhoea) and also no cycles (amenorrhoea) and infertility was demonstrated in three placebo controlled RCTs.

An extract of Chaste Tree was as effective as the pharmaceutical drug Bromocriptine in lowering prolactin on one study and all three and showed a longer luteal phase improved regularity of cycles (Arentz 2014).

Cyperus Rotundus

Cyperus rotundus has anti-oestrogenic properties

  • lowering fluid retention,
  • breast tenderness,
  • improving mood and anxiety,
  • decreasing PMT
  • dysmenorrhea (abdominal pain before your period)
  • decreasing excessive bleeding during a cycle
  • lowering weight.
Deeper understanding:

Cyperus binds to the oestrogen receptor, blocking the receptor from binding to oestrogen; it also inhibits the enzyme aromatase which converts the androgenic hormones Androstenedione and Testosterone to Oestrone and Oestradiol respectively. 

  1. Cyperus is anti-inflammatory blocking prostaglandin E2alpha (PGE2) a pain inducing chemical (eicosonoid),  and the enzyme COX-2 which makes PGE2,.
  2. Cyperus also blocks LPS (lipopolysacchyaride) and NFKB both drivers of inflammation.
  3. Cyperus also blocks interleukin 6 (IL-6) which is a cytokine driver of inflammation. IL-6 is one of the cytokines which may be raised in PCOS.

Cyperus has also been shown to have an anti-proliferative effect meaning it may help prevent cancer.

Hence cyperus is yet another multi-functional nutraceutical in PCOS SUPPORT Hormone Balance having anti-oestrogenic, anti-proliferative and anti-inflammatory properties.

Calcium-D-Glucarate (CDG)

Calcium-D-Glucarate (CDG) are the calcium salts of naturally occurring D-Glucaric Acid which is found in oranges, apples, carrots, grapefruit and brassicas. 

CDG enhances oestrogen removal from the body via the liver. CDG decreases signs of oestrogen dominance including

 

  • anxiety,
  • poor sleep,
  • breast tenderness,
  • fluid retention,
  • weight gain,
  • painful, heavy and long periods.  

Calcium-d-glucarate has shown to lower;

  1. oestrogens
  2. testosterone
  3. inflammation
Deeper insights:

CDG increases glucuronidation. Glucuronidation reactions involve the metabolism of hormones testosterone and oestrogens, polycyclic aromatic hydrocarbons (PAH), benzo(a)pyrene in burnt meat and some pharmaceutical drugs.

Glucuronidation can be affected by abnormal bowel bacteria (dysbiosis). Some bacteria secrete a chemical called beta-glucuronidase which stops glucuronidation and this can affect oestrogen and testosterone removal.

Calcium-D-Glucarate may have an anti-cancer effect by enhancing glucuronidation and mitigating the effect of beta-glucuronidase. High beta glucuronidase has been associated with breast, prostate and colon cancer.

Calcium D-Glucarate has been found to have an anti-inflammatory effect through the promotion of  the anti-inflammatory cytokine  IL-10 which modulates pro-inflammatory cytokines.

Hence in a PCOS setting of hyperoestrogens, hyperandrogens (hyperandrogenism), inflammation, and obesity, Calcium-D-Glucarate is well placed. Facilitate enhanced elimination of oestrogens reducing the potential risk of cancer, weight gain and ovarian dysfunction. Glucuronidation also eliminates testosterone one of many androgens which are major markers of PCOS and responsible for many distressing signs and symptoms and has an anti-inflammatory effect. 

From a PMS standpoint, CDG can effectively remove anxiety, breast tenderness and headaches from oestrogen dominance.

CURCUMIN

Curcumin is the yellow ingredient in the delicious spice Turmeric, long been recognized for its medicinal properties and necessary for tasty curries and desserts. Curcumin has been extensively researched for its antioxidant and anti-inflammatory properties. Curcumin may also inhibit cancer.

 Curcumin for PCOS

PCOS patients suffer low grade chronic inflammation and oxidation. One of the main features of worsening PCOS is the development of Metabolic Syndrome (high blood pressure, high blood sugar, high blood insulin high blood fats-triglycerides, weight gain).

Many factors in PCOS can results in The Metabolic Syndrome, one is inflammation.

Research shows Curcumin

  • reduces the Metabolic Syndrome by lowering inflammation and oxidation
  • assists Pancreatic function
  • reduces insulin resistance
  • improves ovarian function
  • assists weight loss as Curcumin increases fat burning and stops fat accumulation
  • can independently lower blood pressure
  • has been shown to lower ‘bad’ cholesterol (LDL) and raise ‘good’ cholesterol HDL
  • lowers blood fats (triglyerides)
  • blocks one of the major drivers of inflammation called NfKB (nuclear factor kappa beta).

Since overweight and obesity is experienced by 30-70% of PCOS patients and since inflammation  and dysfunctional immune activation is an up-stream mechanism in the inflammatory cascade which assails PCOS patients, to be able to treat weight gain and the pathological reasons behind it with curcumin, is an asset.

Many blood markers of inflammation have been shown to be raised in PCOS including CRP (C-reactive protein) and inflammatory cytokines (TNF alpha, IL-1b, IL-4, VEGF, IL-6, TGFb, MCP-1).

  • Curcumin lowers malondialdehyde (MDA).
  • Curcumin improves depression common in PCOS sufferers.

Curcumin works ‘on many fronts’, lowering inflammation (driven by immune dysfunction) and oxidation that is in part responsible for insulin resistance and the Metabolic Syndrome. 

Curcumin helps lower fat mass by burning fat and stopping fat accumulation. Lowering fat (and weight)can by itself start ovulation and increase the chance of pregnancy).

Curcumin indirectly supports healthy ovarian function by lowering inflammatory factors that disturb ovarian function.

Deeper insights:

Most of these benefits of curcumin can be attributed to its antioxidant boosting SOD, catalase, glutathione peroxidase and its potent anti-inflammatory effects. Curcumin is also anti-mitogenic.

  • Curcumin suppresses reactive oxygen species (ROS) and reactive nitrogen species (RNS) promoting pro-inflammatory gene expression and pro-inflammatory effects.  Hence curcumin provides dual antioxidant and anti-inflammatory protection.
  • Curcumin aids in the management of oxidative and inflammatory conditions, Metabolic Syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery. 
  • Curcumin has been shown to attenuate several aspects of Metabolic Syndrome by improving insulin sensitivity. Curcumin improves overall function of pancreatic β-cells, supporting healthy insulin function.
  • Cytokines are involved in the development of metabolic abnormalities that may result in metabolic syndrome (MetS). PCOS sufferers are at risk of MetS.
  • Curcumin may improve improve MetS (hyperglycaemia, hyperinsulinemia, visceral obesity, high cholesterol, hypertriglyceridemia)
  • Curcumin lowers many inflammatory cytokines which may be raised in PCOS (TNF alpha, IL-1beta, IL-6 and others).

PCOS is an inflammatory process, with raised inflammatory cytokines whose origin is likely genetic and possibly epigenetic (lifestyle, diet, stressors). To treat Metabolic Syndrome with standard care, would typically miss the underlying inflammatory mechanism. 

Curcumin has been shown to attenuate several aspects of MetS by not only improving insulin sensitivity but also suppressing adipogenesis. Curcumin directly interacts with white adipose tissue to suppress chronic inflammation. In adipose tissue, curcumin inhibits macrophage infiltration and nuclear factor κB (NF-κB) activation induced by inflammatory agents. Curcumin reduces the expression of the potent pro-inflammatory adipokines tumor necrosis factor-α (TNFα), monocyte chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 (PAI-1), and it induces the expression of adiponectin, the principal anti-inflammatory agent secreted by adipocytes. 

Curcumin has effects to inhibit adipocyte diff
erentiation and to promote antioxidant activities. Through these diverse mechanisms curcumin reduces obesity and curtails the adverse health effects of obesity (Bradford 2013).

Hence curcumin is a ‘base’ nutritional intervention across vast swathes of pathophysiology that besets a PCOS sufferer. It is an integral member of PCOS SUPPORT and champions many regulatory features, including inflammation which it targets both at the level of cytokines but also at a nuclear inflammatory promoter level downregulating Nf-KB. Furthermore, at a tissue level Curcumin reduces COX and LOX eicosanoids lowering Prostaglandin E2 alpha (PGE2).

Through this anti-inflammatory and antioxidant intervention many of the signs and symptoms of PCOS are addressed.

Curcumin in PCOS SUPPORT Hormone Balance is the high bio-available BCM-95.

Conclusion:

At Life Source, the creation of PCOS SUPPORT Metabolic Balance and Hormone Balance addresses many of the hidden nuances in this very complex condition.

This highly researched and well considered PCOS Support formula by Dr. Russell P. Cooper, has been designed to be the ultimate baseline PCOS supplement and has garnered incredible results.

100% natural, Veg-caps, PCOS Support is made with the highest quality ingredients sourced from around the world.

PCOS Support helping you achieve the ‘Art of Being’

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